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arXiv:2601.19002v1 Announce Type: new Abstract: Single-stranded whole-genome bisulfite sequencing (ssWGBS) enables DNA methylation profiling in low-input and highly fragmented samples, including cell-free DNA, but introduces...
arXiv:2601.19019v1 Announce Type: new Abstract: Recurrent neural networks trained for time-series prediction often develop latent trajectories that preserve qualitative structure of the dynamical systems generating...
arXiv:2601.19064v1 Announce Type: new Abstract: There are few, if any, algorithms in statistical phylogenetics which are used more heavily than Felsenstein's 1973 pruning method for...
arXiv:2601.19125v1 Announce Type: new Abstract: Visual illusions provide a window into the mechanisms underlying visual processing, and dynamical neural circuit models offer a natural framework...
arXiv:2601.19205v1 Announce Type: new Abstract: Designing enzymes with substrate-binding pockets is a critical challenge in protein engineering, as catalytic activity depends on the precise interaction...
arXiv:2601.19257v1 Announce Type: new Abstract: Molecular representation learning aims to learn vector embeddings that capture molecular structure and geometry, thereby enabling property prediction and downstream...
arXiv:2601.19681v1 Announce Type: new Abstract: Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target...
arXiv:2601.19852v1 Announce Type: new Abstract: Tumor growth is constrained by spatial, mechanical, and metabolic factors whose alignment progressively breaks down across cellular, mesoscopic, and tissue...
arXiv:2601.18921v1 Announce Type: cross Abstract: The integration of large-scale chemical databases represents a critical bottleneck in modern cheminformatics research, particularly for machine learning applications requiring...
arXiv:2601.19037v1 Announce Type: cross Abstract: Accurate molecular property prediction is central to drug discovery, yet graph neural networks often underperform in data-scarce regimes and fail...
arXiv:2601.19149v1 Announce Type: cross Abstract: G protein-coupled receptors (GPCRs) govern diverse physiological processes and are central to modern pharmacology. Yet discovering GPCR modulators remains challenging...
arXiv:2601.19384v1 Announce Type: cross Abstract: Genome sequencing has become a central focus in computational biology. A genome study typically begins with sequencing, which produces millions...
arXiv:2406.06765v3 Announce Type: replace Abstract: Mathematical modeling allows us to better understand myeloproliferative neoplasms (MPN), a group of blood cancers, emergence and development. We test...
arXiv:2412.00008v3 Announce Type: replace Abstract: On broadly Copernican grounds, we are entitled to assume that apparently behaviorally sophisticated extraterrestrial entities ("aliens") would be conscious. Otherwise,...
arXiv:2506.11062v2 Announce Type: replace Abstract: A central idea in understanding brains and building artificial intelligence is that structure determines function. Yet, how the brain's complex...
arXiv:2509.15278v3 Announce Type: replace Abstract: The ethical and legal imperative to share research data without causing harm requires careful attention to privacy risks. While mounting...
arXiv:2601.11018v2 Announce Type: replace Abstract: Exposure to psychoactive substances during pregnancy, such as cannabis, can disrupt neurodevelopment and alter large-scale brain networks, yet identifying their...
arXiv:2601.13349v2 Announce Type: replace Abstract: Diseases originating from wildlife pose a significant threat to global health, causing human and economic losses each year. The transmission...
arXiv:2403.18602v2 Announce Type: replace-cross Abstract: Motivation: In recent years, the availability of multi-omics data has increased substantially. Multi-omics data integration methods mainly aim to leverage...
arXiv:2406.16821v2 Announce Type: replace-cross Abstract: Structure-based drug design (SBDD) aims to generate ligands that bind strongly and specifically to target protein pockets. Recent diffusion models...
arXiv:2507.14056v2 Announce Type: replace-cross Abstract: Recent work in continual learning has highlighted the stability gap -- a temporary performance drop on previously learned tasks when...
arXiv:2601.11013v2 Announce Type: replace-cross Abstract: A continuous route from a disordered soup of simple chemical feedstocks to a functional protocell -- a compartment that metabolizes,...
arXiv:2601.18604v2 Announce Type: replace-cross Abstract: Motivation: Pathway enrichment analysis is widely used to interpret gene expression data. Standard approaches, such as GSEA, rely on predefined...
arXiv:2601.18640v2 Announce Type: replace-cross Abstract: Advances in single-cell and spatial transcriptomic technologies have transformed tumor ecosystem profiling at cellular resolution. However, large scale studies on...